Nanosponge: An innovative drug carrier system - a review

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

Mamidi Hemanth Kumar

Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

Drug targeting and enhancing the bioavailability of poorly water soluble drugs by an effective drug delivery system has been a dream for a long time. Designing of effective drug delivery system by using nanotechnology has gained importance in recent times. Nanosponge is one of such effective drug delivery system which overcome the problems of drug toxicity and poor bioavailability. Nanosponges are innovative carriers which are about a size of a virus with a 3-dimensional network or scaffold structure and a nanometric cavity size. These can act as the carriers for several hydrophilic and lipophilic drugs which have poor aqueous solubility. The backbone is a long length of polyester which is mixed in solution with small molecules called cross-linkers that act like tiny grappling hooks to fasten different parts of the polymer together. The net effect is to form spherically shaped particles filled with cavities where drug molecules can be stored. By the attachment of specific peptide linkers, nanosponges are targeted to specific sites in the body thus minimize the adverse effects and increase the efficiency of the drug. It holds a promising future in various pharmaceutical applications in the coming years like enhanced product performance and elegancy, extended release, reduced irritation, improved thermal, physical, and chemical stability of product. In this review, an attempt is made to summarize the methods of development, characterization, applications and future of this innovative carrier system.

Biography :

Mamidi Hemanth Kumar completed Bachelors in Pharmacy from JNTU- Hyderabad and now he is pursuing his Masters in Pharmacy (second semester) from Anurag group of institution, School of Pharmacy.