Neuroprotective role of argan oil against the development of status epilepticus in lithium-pilocarpine model of temporal lobe epilepsy in the Wistar rat

2^nd International Conference on Epilepsy & Treatment

October 20-21, 2016 Rome, Italy

Ammouri H, Bahbiti Y, Ouichou A, El Hessni A, Nakache R, Berkiks I, Bekjdaouene L and Mesfioui A

Laboratory of Neuroendocrinology , Genetics and Biotechnology, Morocco

Posters & Accepted Abstracts: J Neurol Disord

Abstract :

Temporal lobe epilepsy (TLE) is the most common form of human epilepsy. Patients with TLE often have a clinical history including an initial precipitating injury, such as status epilepticus (SE). In this regard, neuroprotective treatments are considered a promising therapy for preventing and treating TLE. Thus, being well known for its physical and chemical composition, particularly vitamin E and unsaturated essential fatty acids, we are interested in argan oil pretreatment in order to examine the neuroprotective effects on the development and severity of SE in lithium-pilocarpine (Li-PC) model of TLE. Wistar rats (21 days of age) were gavaged daily with argan oil or with NaCl (1 ml/100 g) during 3 months. SE was induced in adult rats by lithium (3 mEq/kg) followed 18 h later by pilocarpine (30 mg/kg), yet it is interrupted by diazepam (10 mg/kg) in all rats. SE severity and Racine stages are assessed by video-recording. The results of our study showed that pretreatment with argan oil have decreased the intensity of seizures. And the high percentage of resistance against the development of EDM and duration of prolonged silent phase in the group treated with argan oil. The current study suggests that argan oil pretreatment is capable of attenuating seizure severity of Li-PC induced SE. This indicates that argan oil provides a neuroprotection against the TLE.

Biography :

Email: amouri300@outlook.fr