New catalytic application of modified graphene in synthesis of biologically active heterocycles

Joint Conference: International Conference on DIAMOND AND CARBON MATERIALS & GRAPHENE AND SEMICONDUCTORS

July 17-18, 2017 Chicago, USA

Saeid Khodabakhshi

IMDEA Nano Science Institute, Spain

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

So far, various heterogenous catalysts have been used for organic reactions, but metal-free catalysts have attracted much attention in recent years. Metal-free carbon-based catalysts have some advantages over metal catalysts, such as high efficiency, environmental compatibility, low energy consumption, and corrosion resistance. Among metal-free materials having catalytic properties, carbon-based catalysts such as modified graphene and nanotubes are emerging. Using graphene oxide (GO) as non-oxidative catalysts to promote and facilitate organic reactions in particular the condensations of the active methylenes is a new area with outstanding potential. In fact, the acidic nature of GO provides active sites to promote organic reactions which need the mild acidic conditions. GO and its related materials have some advantages over many common catalysts including stability, safety, insolubility in common solvents, and recyclability make them recyclable catalysts for many chemical reactions. However, the catalytic application of graphene has focused primarily on the use of these materials as a support for catalytically active transition metals. Despite the merits of graphene materials, their application as catalyst in synthetic chemistry remains unexplored. Accordingly, here we explain the use of GO as a metal-free, eco-friendly and recyclable catalyst for the convenient synthesis of some biologically active compounds containing aryloyl group in green conditions. The reaction of 4-hydroxycoumarin with aryl glyoxals and malononitrile in the presence of graphene oxide provides a simple one-pot entry to the synthesis of some biscoumarins and pyranocoumarins of potential pharmaceutical and synthetic interest. The present methods have some advantages such as the use of a safe and recyclable catalyst, avoidance of toxic solvents, high product yields, short reaction times, and an easy work-up procedure.

Biography :

Email: saeidkhm@yahoo.com