Non-smoking causes of primary lung cancer

International Conference and Exhibition on Lung Disorders & Therapeutics

July 13-15, 2015 Baltimore, Maryland, USA

Hasleton P S1 and Quinn A M2

Posters-Accepted Abstracts: J Pulm Respir Med

Abstract :

Up to 25% of lung cancer cases worldwide can arise in never smokers. As fewer people smoke in the West, it is now important to consider the non-smoking causes of primary lung carcinoma, as steps will be needed to identify susceptible individuals early, so prevention and/or early diagnosis can be made. We will consider if there is a predisposition for individual (histological) types of carcinoma, polymorphisms may account for differences in response to exposure and if there is a familial predisposition to develop lung cancer. Second-hand smoke alone is not thought to induce cancer, without other factors. Different polymorphisms are described for smokers and recently in never smokers. Epigenetic factors have also been discovered. Occupational factors are considered, such as asbestos and if there needs to be fibrosis for the carcinoma to develop. Nickel, Chromium, Beryllium, Radon and chlorinated solvents will be mentioned. Lifestyle effects, such as cooking (fumes in poorlyventilated areas from oils), and coal fume exposure, which is possibly due to a polymorphism of glutathione S-transferase. Lifestyle effects such as obesity, dietary factors, including the intake of vegetables with antioxidant properties (carrots, greens), smoking marijuana, bidis and the effect of social class will be discussed, as well as cancers arising post chemotherapy, single nucleotide polymorphisms can affect response to chemotherapy and post radiotherapy.