Overview of hepatitis B viral mutations associated hepatocellular carcinoma

26^th World Cancer and Oncodiagnostics Conference

November 27-28, 2017 Dubai, UAE

Yuehua Huang, Lin Gu, Yanlin Huang and Jinqi You

Sun Yat- sen University, China
Presee Biotechnology Co. Ltd, China

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

Chronic infection with hepatitis B virus (HBV) greatly increases the risk of hepatocellular carcinoma (HCC). High viral load, genotype C and HBV mutations have been reported to be independently associated with an increased risk of HCC. Mutations in different parts of the viral genome occur due to the stress from humoral and cell-mediated immunities during the immune clearance phase. Core promoter mutations, preS deletions and C-terminal truncation of envelope proteins are associated with HCC development. The core promoter mutants are not only associated with an increased risk of HCC development but have direct relationship with poor survival in postoperative HCC patients. Combined mutations from different regions in HBV genome show synergistic effects on HCC risk. The prolonged expression of these altered versions of core promoter proteins and preS/S envelope proteins dysregulates cell transcription, proliferation, apoptosis, and angiogenesis and therefore sensitizes liver cells to carcinogenic factors. This paper provides an overview of the HBV mutations that are related to HCC development and progression in terms of their biological properties and clinical significance.