Oxidative status evaluation in tumor tissue of patients with colorectal cancer (CRC)

5^th World Congress on Cancer Therapy

September 28-30, 2015 Atlanta, USA

Jesus Crespo-Sanjuan1, Cristina Andres-Ledesma1, M D Calvo-Nieves1, B Velayos-Jimenez1, Herreros-Rodri�­guez1, H Nunz-Barrio1, J R Oliva-Ramos3, N Zamora-Gonzalez3, P Bueno-Requena1 M D Ganfornina2, D Sanchez2 and E Largo-Cabrerizo1

1Hospital Clinico Universitario de Valladolid
2IBGM- Universidad de Valladolid
3Hospital Universitario Ri�­o Hortega de Valladolid

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Mucosal inflammation and oxidative stress are causes of CRC, which leads to the formation of polyps and degeneration into adenocarcinoma. We evaluated the oxidative state in the mucosa by analysis of peroxidized lipids in both tumor and normal mucosa. PURPOSE: To analyze levels of oxidative stress in tissue of patients with CRC, with polyps and control patients. Methods: The tumor was resected and tissue was homogenized to measure peroxidized lipids by TBARS. The SPSSR program was used for statistical analysis, using descriptive statistics and Kruskal-Wallis. Result: TBARS values obtained in the mucosa of cancer patients (mean 24.91) were higher than in the mucosa of patients with polyps (15.65). Higher values are also obtained in patients with polyps than in control patients (3.74). (P <0.005)Patients taking statins have lower TBARS values. (P <0.005) Nos association was found with age or sex. (P <0.005). Conclusion: We can state that peroxidized lipids increase in tumor tissue and that this increase begins at the polyp stage. We believe that there is a high basal oxidation state in these patients that predisposes them to the formation of precancerous polyps. If we detect this condition at an early stage we will be more effective in preventing disease. This increase is not associated with age or sex of patients. Moreover, patients who consume more statins have decreased levels of peroxidized lipids and this fact suggests that this drug could be useful to prevent CRC.

Biography :

Email: pmpeius@hotmail.com