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Oxidative-coupling reaction-based sensitive determination of dopamine at glassy carbon electrode using chronoamperometry
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Chemical Sciences Journal

ISSN: 2150-3494

Open Access

Oxidative-coupling reaction-based sensitive determination of dopamine at glassy carbon electrode using chronoamperometry


5th International Conference on Organic and Inorganic Chemistry

July 12-13, 2018 | Paris, France

W Boumya

Hassan Premier University, Morocco

Posters & Accepted Abstracts: J Chemical Sci

Abstract :

A simple and rapid method based on oxidative-coupling reaction for determination of dopamine using chronoamperometry was developed. Based on oxidative-coupling reaction, dopamine was transformed into red azo dye by reacting with 2,4-dinitrophenylhydrazine (DNPH) oxidized. Subsequently, the concentration of dopamine can be determined indirectly from azo dye. Taking account of the advantage of their low-cost and the convenience in manipulation, chronoamperometry was employed to investigate the response of dopamine-derived azo dye. Square wave voltammetry and impedimetric studies were done to characterize the dopamine-derived azo dye. Various factors that influence reaction and amperometric intensity were investigated. Under the optimal conditions, the linearity was observed in the range of 0.1ΓΆΒ?Β?0.0005 mmol L-1 with good correlation coefficient (R2= 0.9793). The relative standard deviation (RSDs) for five replicate measurements 3.37 %. The limit of detections of the method (S/N=3) was 0.02.36 mmol L-1. The performance of the proposed method to determine the concentration of dopamine in pharmaceuticals samples was evaluated.

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