Muhammed D Al-Jarrah, Nour S Erekat
Department of Rehabilitation Sciences. Faculty of Applied Medical Sciences. JUST. Irbid 22110, Jordan
Department of Anatomy. Faculty of Medicine. Jordan University of Science and Technology (JUST). Irbid 22110, Jordan
Scientific Tracks Abstracts: J Neurol Disord
Background: We have shown elevated levels of p53 and active caspase-3 in gastrocnemius skeletal muscle with Parkinson�s disease (PD). The main aim of this study is to examine the impact of endurance exercise training on the expression of p53 and active caspase-3 in the skeletal muscle of mouse with induced Parkinsonism. Methods: Sedentary control (SC), sedentary Parkinson diseased (SPD), and exercised Parkinson diseased (EPD) groups were formed; each consisting of 10 randomly selected normal albino mice. Chronic Parkinson disease was induced in the SPD and EPD animals using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid (MPTP/p). The expression of p53 and active caspase-3 was investigated, using immunohistochemistry, in the gastrocnemius muscle in each animal group. Results: Both p53 and active caspase-3 expression was significantly (p value < 0.05) reduced in the PD gastrocnemius skeletal muscle following endurance exercise training. Conclusion: Our present data suggest that chronic exercise training reduced Parkinson disease-induced upregulation of p53 and active caspase-3 in gastrocnemius skeletal muscle. Thus, our study suggests that inhibiting p53 and/or active caspase-3 may be considered as a therapeutic approach to ameliorate PD skeletal muscle abnormalities.
Muhammed Al-Jarrah PhD, PT is a part of Jordan University of Science and Technology working as Faculty of Applied Medical sciences in Department of Rehabilitation Sciences, Irbid – Jordan.
Email: jarrahm@just.edu.jo
Neurological Disorders received 1343 citations as per Google Scholar report
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