Patient-specific modeling of disease: When are iPS cell-based designs inappropriate

Global Congress on Tissue Engineering, Regenerative & Precision Medicine

December 1-2, 2016 | San Antonio, USA

Jose Javier Otero

The Ohio State University College of Medicine, USA

Posters & Accepted Abstracts: J Tissue Sci Eng

Abstract :

Patient specific modeling has provided key insight into the mechanisms of human disease. In particular, the opportunity to utilize model systems such as induced pluripotent stem cells or murine animal models has invaluably increased the tool box available to pathobiologists. However, choosing which model is optimal for translation can prove difficult. Here, we present findings of Congenital Central Hypoventilation Syndrome, a rare human disorder that result in an impaired response to CO2 in human patients. We developed patient specific iPS cell and transgenic mouse models of this disease, which provide insight into ventilator control in humans. We also discuss the appropriateness of iPS cell versus murine models in studying human disease.

Biography :

Email: jose.otero@osumc.edu