Mzia Zhvania, Mariam Ksovreli, Nino Fochkhidze and Nadezhda Japaridze
Ilia State University, Georgia
Posters-Accepted Abstracts: J Neurol Disord
Post status epilepticus model is provoked by single, systemic or local administration of convulsive dose of epilepsy-produced drug or electrical stimulation. This model closely resemble some forms of human epilepsy when acute episode of seizures also known as status epilepticus is followed by a latency period with subsequent seizure activities, enhanced neuronal excitability and specific biochemical, molecular and structural alterations in epileptogenic regions of brain. While behavioral, electrophysiological and molecular alterations accompanying post status epilepticus have been studied intensively, corresponding structural modifications are described only in a few studies. A Pentylenetetrazol (PTZ)-induced status epilepticus model in rats was used. The brains were studied one month after treatment. Electron-microscopic observations performed in the hippocampal CA1 region of epileptic brains demonstrated the following major changes over normal brain: The ultra-structure of some neurons, synapses and glial cells is pathologically altered; the alterations are found to be dependent on the frequency of seizure activities following treatment. If seizure episodes are frequent and severe, the hippocampal ultra-structure is significantly changed. The area is found to be only moderately altered if seizure episodes following status epilepticus are rare and more superficial; alterations in mitochondria and dendrites are the most common ultra-structural changes seen suggesting cell stress and changes to cellular metabolism. Such altered morphology is a reflection of epileptic pathophysiology. Further studies at the chemical and molecular level will further reveal the nature of these changes.
Email: mzia_zhvania@iliauni.edu.ge
Neurological Disorders received 1343 citations as per Google Scholar report
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