Pharmacological evaluation of sedative and hypnotic activity of ethyl p-methoxycinnamate and n-hydroxyethyl-p-cinnamamide

2^nd International Conference on PHARMACEUTICAL CHEMISTRY

October 02-04, 2017 Barcelona, Spain

Nurmeilis, Azrifitria, Ismiarni Komala and Nita Fitriani

Syarif Hidayatullah State Islamic University Jakarta, Indonesia

Scientific Tracks Abstracts: Med Chem (Los Angeles)

Abstract :

Ethyl p-methoxycinnamate (1) was found as a major isolated compound from the rhizome of Kaempferia galanga. This compound has been reported to have various biological activities such as mosquito repellent and larvicidal, anti-tuberculosis, sedative, anticancer, analgesic and anti-inflammatory and hypo pigmentary. In this research, we have evaluated the sedative and hypnotic activity of 1 and its amide derivative, N-hydroxyethyl-p-cinnamamide (2). The method was carried out by evaluating significant sedative and hypnotic effect of 1 and 2 at the doses of 100, 200 and 400 mg/kg (by oral route), compared to reference substance diazepam in hole board and thiopental-induced sleeping time methods. In conclusion, compound 1 has 2 has a potential sedative and hypnotic activity, whereas compound 1 was significantly different to the negative control (p�0.05).

Biography :

Nurmeilis has completed her Doctoral Studies at Universitas of Indonesia with majoring of Pharmacy and working as a Lecturer in Pharmacy Department, Faculty of Medicine and Health Sciences, Syarif Hidayatullah State Islamic University and now as a Head of program study of Pharmacy.