Photo modulation effect of low level laser therapy against radiation induced oral mucositis in head and neck cancer patients-A randomized clinical trial

9^th Indo Global Summit on Cancer Therapy

November 02-04, 2015 Hyderabad, India

G Arun Maiya, M S Vidya Sagar, Donald Fernandes and Stephen Samuel

Manipal University, India

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Background & Objectives: Radiotherapy (RT) is treatment of choice for Head and Neck Cancer (HNC) patients. Oral mucositis (OM) during radiation affects patientâ��s overall health. Therefore, the objective of the study is to find the photo modulation effect of Low Level Laser Therapy (LLLT) against radiation induced oral mucositis in head and neck cancer patients. Material & Methods: This double blinded study randomized 56 HNC patients scheduled for RT [Dosage=66 Gray (2Gy/fraction), 5 fractions/week, total 33 fractions for 6.5 weeks], into Laser (28) and Placebo (28) groups. Laser group patients received LLLT [Helium-Neon, �»=632.8nm, Power-density=0.024W, Dosage=3.0J/point, total dosage/session=36-40J, spot-size=1cm2, 15-20min/ session, 5 sessions/week), whereas placebo group did not receive laser. OM grades (RTOG/EORTC scale), oral pain, weight loss, need for morphine analgesics and tube feeding and RT break were recorded by a blinded assessor. Descriptive statistics and tests of repeated measures were used for analysis keeping p<0.05. Results: Significant reduction in the incidence and duration of severe OM (p=0.001) and severe pain (p=0.020) and weight loss (p=0.005) was observed in laser than placebo group. Conclusions: LLLT decreased the severity of OM and oral pain in HNC patients. In addition we observed lesser weight loss, morphine analgesic use and radiation break happened in laser group.

Biography :

Email: ajmaiya@yahoo.com