Physicochemical and mechanical evaluation of a novel theophylline and 4-aminobenzoic acid pharmaceutical co-crystals

9^th World Congress on Materials Science and Engineering

June 12-14, 2017 Rome, Italy

Rahamatullah Shaikh, Denise Croker and Gavin M Walker

University of Limerick, Republic of Ireland

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

Statement of the Problem: Pharmaceutical cocrystals are solids that are crystalline materials comprise of two or more components held together by non-covalent forces. In recent years co-crystals are being studied intensively due to the potential for improved pharmaceutical properties such as increased solubility, bioavailability, chemical stability and hygroscopicity of active pharmaceutical ingredients. A crystalline particle is characterized by definite crystal habit which relates to the external structure (such as shape and size) and crystal lattice describes the internal structures. Change in crystal forms has significant effect on drug particle mechanical properties (particle strength, flowability, miscibility and tableting) dissolution rate and stability. To enhance understanding of cocrystallization process on mechanical properties of Theophylline (active pharmaceutical ingredient) in the present study the impact of crystal structure and its relationship with powder compaction has been investigated. Methodology: Novel theophylline and 4-aminobenzoic acid pharmaceutical co-crystals at molar ratio of 1:1 were synthesized by solvent evaporation and mechano-chemical synthesis techniques. Co-crystals were mainly characterized by powder X-ray diffraction (PXRPD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR) and single crystal X-ray diffraction. Theophylline cocrystals were also subjected to powder flow, powder compaction and relative humidity stability testing studies. Findings & Significance: The molecular structure of the novel theophylline and 4-aminobenzoic acid pharmaceutical cocrystal was further confirmed using single crystal X-ray diffraction analysis. Finally crystal structure and its relationship can be considered for improving mechanical properties of API.

Biography :

Email: Rahamatullah.Shaikh@ul.ie