Phytoimmunotherapy: A new approach for cancer treatment

9^th Indo Global Summit on Cancer Therapy

November 02-04, 2015 Hyderabad, India

Bhatia Aruna1, Sheikh Abid Ali1, Mishra Tulika1, Khera Nishu1, Parvaiz Q2, D M Mondhe2 and Abid Hamid2

1Punjabi University, India 2CSIR-Indian Institute of Integrative Medicine, India

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Cancer is the most deadly disease of today which figures among the leading causes of death worldwide, accounting for 8.2 million deaths in 2012 and it is expected that annual cases will rises from 14 million in 2012 to 22 million within next two decades. Cancer is usually treated with chemotherapy, radiotherapy and surgery which have many side effects. Recent advances prove the role of immune response of body in cancer prevention and treatment. Immune response of body can be modulated by environmental factors, food, stress etc. Since ages, the medicinal plants in the form of extracts or their phytochemicals have been employed as therapeutic agents. In our lab, since past 27 years the work is going on to find out the impact of plant extracts and their phytochemicals on modulation of immune response which in turn is applied to cure or combat various diseases with emphasis on cancer therapy. In recent studies, extracts of four plants i.e., Ziziphus mauritiana, Woodfordia fruticosa and Prunus cerasus were tested for immunomodulatory and anti-cancerous activity. Methanolic fruit extract of Prunus cerasus (PcMFE) was found to be the best immunomodulators; hence, it was further evaluated for its anti-cancerous activity. In addition, PcMFE was subjected to chromatography for phytochemical isolation. Four major compounds i.e., Chlorogenic acid, Rutin, Quercetin, Diadzein were isolated and tested for their anti-cancerous activity against different cell lines in vitro and later in vivo studies were carried out with best selected compound. EAC ascites reduction and solid tumor growth inhibition were the parameters employed. The extract inhibited the tumor growth to a tune of 52% and a quercetin was found to be the best tumor inhibitor up to 89%. 5 FU was used as a control. It was concluded that P. cerasus or its compounds can be employed as an alternative and safe anti-cancerous therapeutic agent. In addition to P. cerasus, methanolic extracts and their compounds, seed extract of Z. mauritiana and flower extract of W. fruticosa were also found to be anti-cancerous. Experiments are being carried out in the lab to improve the bio-efficacy of these extracts through nano-delivery in vivo.

Biography :

Email: aruna_bhatia@rediffmail.com