Waleed Abdou Ibrahim Hamed,Nevein M Al-sheikh, Wafaa A Shehata and Shaimaa A Hassanein
Menoufia University, Egypt
Scientific Tracks Abstracts: J Cardiovasc Dis Diagn
Background & Objectives: Chemerin, leptin and psoriasin are proinflammatory
and immune-modulatory proteins associated with psoriasis and
displayed higher circulating levels. Their relation to atherosclerosis in psoriatic
patients has been investigated in numerous studies with wide-ranging results.
Therefore, the present study aimed to assess plasma levels of chemerin, leptin
and psoriasin and evaluate their relationship with carotid intima-media thickness
(CIMT) and epicardial fat thickness (EFT) as potential predictors for subclinical
atherosclerosis in psoriasis patients.
Patients & Methods: The study included 50 psoriatic patients and 40 age and
gender matched healthy controls. Clinical severity of psoriasis was evaluated by
psoriasis area and severity index (PASI). Fasting blood glucose and lipid profile
were estimated. Plasma levels of high sensitivity-CRP (hs-CRP), chemerin,
leptin and psoriasin were measured by ELISA. CIMT and EFT were assessed by
ultrasonography and echocardiography, respectively.
Results: Plasma levels of hs-CRP, chemerin, leptin and psoriasin as well as CIMT
and EFT were significantly elevated in psoriasis patients compared to controls
(P<0.001). CIMT and EFT were significantly positively correlated with PASI,
plasma hs-CRP, chemerin, leptin and psoriasin (P<0.001). Moreover, significant
positive correlation was demonstrated between PASI and plasma hs-CRP,
chemerin, leptin and psoriasin (P<0.001). Multiple linear regression analyses
showed that chemerin, leptin and psoriasin were independently correlated with
CIMT and EFT and exhibited high significance for predicting their values.
Conclusion: It can be concluded that chemerin, leptin and psoriasin might
represent an important link between psoriasis and atherosclerosis. Measurements
of plasma chemerin, leptin and psoriasin along with CIMT and EFT seem to
be valuable potential markers of subclinical atherosclerosis in patients with
psoriasis.
Waleed Abdou Ibrahim Hamed has completed his MD degree from Menoufia University. He is Assistant Professor of Cardiology in Faculty of Medicine, Menoufia University. He has published more than 30 papers in different cardiology journals and conferences.
E-mail: waleedabdou@yahoo.com
Cardiovascular Diseases & Diagnosis received 427 citations as per Google Scholar report