Leonor Girao,Manuel Fitas, Pedro Contreiras Pinto
Clinica Dermatologia do Areeiro, Portugal
PhD Trials R&D Department, Lisbon,Portugal
University of Lisbon, Portugal
Keynote: J Cosmo Trichol
Introduction & Objectives: Platelet-rich Plasma (PRP) has been shown
to improve skin function parameters like skin elasticity and angiogenesis
by release and degranulation of growth factors and cytokines. The present
study uses bioengineering methods to evaluate skin specific functional
parameters and collagen reestablishment and neo-synthesis by Confocal
Laser Scanning Microscopy (LSCM) in a group of patients with photo
aging submitted to PRP treatments during 3 months.
Materials & Methods: 12 patients were submitted to a PRP treatment,
due to photo aging on the face. After a phlebotomy, a PRP preparation was
obtained, a local anesthetic was applied, and administration on the affected
area by SC injection was performed at D0, D30 and D60. All the patients
were evaluated for wrinkle 3D parameters, collagen quantification, and
Photo aging parameters through Primos 3D, LSCM and VISIA-CR systems
before and after each treatment.
Results & Discussion: Results show a 36, 6 % wrinkle reduction on both
crow’s feet and nasolabial fold areas. Regarding collagen formation and
reorganization, there was a 9,3 % increase in both parameters after the end
of the study. Finally, results suggest a decrease in the Brown and UV spots
evaluated by VISIA-CR system. These findings suggest a neo-synthesis of
collagen and other matrix components, probably due to activation and
proliferation of fibroblasts that improves the skin appearance and reverts in
a significant way some effects of photo aging.
Conclusions: Skin improvement was observed in during the treatments.
The results, particularly the collagen formation and reorganization, suggest
an effect on dermis functionality that improves skin condition in photo
aging patients.
Leonor Girao is a Medical Doctor in Dermatology and Venereology, Lisbon, Portugal. She is the Chief Dermatologist in Dermatologia do Areeiro Clinic, Lisbon, Portugal and also chief Dermatologist in the PhD Trials a Contact Research Enterprise. She has work experience in Aesthetics Dermatology as well as General Dermatology, Pediatric Dermatology, Mycology, and Dermatosurgery. She has been a regular speaker in several National and International Dermatological meetings. She is also a Member of Portuguese Society of Dermatology and Venereology Member of Portuguese Society of Cosmetology. She is also a Member of Portuguese Association of Skin Cancer.
E-mail: girao.leonor@gmail.com
Journal of Cosmetology & Trichology received 180 citations as per Google Scholar report