PM10-bound polycyclic aromatic hydrocarbons: A key factor in lung carcinogenicity in urban environments under heavy sources of emission

3^rd World Congress on Cancer Science & Therapy

October 21-23, 2013 DoubleTree by Hilton Hotel San Francisco Airport, CA, USA

A. P. Wickramasinghe

Accepted Abstracts: J Cancer Sci Ther

Abstract :

Polycyclic aromatic hydrocarbons (PAHs), one of persistent organic pollutants ubiquitous in the atmosphere, may be a major etiological factor in lung carcinogenicity. This lecture primarily will address the development and optimization of RP-HPLC/UV based analytical method for the routine identification and quantification of US EPA prioritized 16 PAHs with subsequent application for assessing inhalation exposure levels of PM 10 -PAHs and their source apportionment at different morphological and demographical localities in the world heritage city Kandy, Sri Lanka. Over the high levels of PAHs and associated risks, the discussion will focus on setting priorities for prevention of cancer through control of human exposure to PAHs in Kandy, but applicable to similar cities in the world too. Accordingly, instead of the conventional practice of risk quantification with ?continuous lifetime exposure?, which seems to be truly ?theoretic?, I suggest probabilistically modified framework to the point estimate approach of risk assessment with more realistic exposure scenarios for ?less-than-lifetime exposures? averaging over critical windows of exposure to determine how the effects vary with dose and/or duration, comparably based on both ?B[a]P toxic equivalents approach? and ?B[a]P surrogate epidemiological approach? of risk quantification under different source scenarios. Furthermore, it addresses the toxicological importance of the atmospheric air PAH concentration and evaluates for the biological indicators of ambient air PAHs in general as well as under different sources of emission in Kandy, with re-appraisal on occupationally based classical indicator B[a]P. In addition the house will be illustrated with evidence-based risk managerial strategies using ?source-exposure-effect relationship? established in Kandy.

Biography :

A. P. Wickramasinghe graduated with honours from the Faculty of Veterinary Medicine & Animal Science, University of Peradeniya with distinctions, gold medal and scholarship for the best performance in 1994. After her PG Dip in EPC Eng (2005), she obtained the Ph.D. in Environmental Sciences from the Faculty of Engineering, University of Peradeniya, Sri Lanka in 2012. While her work has been published in Atmospheric Environment, (2011) and Chemosphere (2012) with reproduction by many, she has presented at international conference ?Planet under Pressure-2012? in London. Dr. Wickramasinghe has served as an invited reviewer for ?Atmospheric Environment? and ?Atmospheric Pollution Research?.