Poly(2-methyl-2-oxazoline)-based non-fouling thin films for biomaterial applications: Relating molecular architecture and resistance to protein adsorption and bacteria adhesion

2^nd International Conference and Exhibition on Materials Science & Engineering

October 07-09, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Bidhari Pidhatika

Accepted Abstracts: J Material Sci

Abstract :

The development of non-fouling materials for biological and medical applications is a broad and expanding field of study. In this context, poly(ethylene glycol) (PEG) has been the most reported polymer for the coating of different surfaces to convey non-fouling properties. Nevertheless, several limitations of PEG-based technology have been reported. Alternative to PEG, we have previously shown that poly(2-methyl-2-oxazoline) (PMOXA) conveys non-fouling properties to the same extent as PEG. Briefly, poly(L-Lysine)- graft -PMOXA (PLL-g-PMOXA, was immobilized onto negatively charged surfaces through electrostatic interactions between the positively charged backbone and the negatively charged surface. Depending on grafting ratio (g = number of lysine residues per number of PMOXA chain), PLL-g-PMOXA formed polymer brush on the surface. Here the hydration, the swollen thickness as well as the stretching of the brush were evaluated, and the homogeneity of the adlayers was probed. These parameters are then related to the adlayers capability to resist non-specific protein adsorption and bacteria adhesion. Methods used include highly surface-sensitive techniques i.e., optical waveguide lightmode spectroscopy (OWLS), quartz crystal microbalance/dissipation (QCM/D), and secondary ion mass spectrometry (SIMS).

Biography :

Bidhari Pidhatika, 33 year old, got his bachelor?s degree in Chemical Engineering from Gadjah Mada University (Indonesia, 2003), master?s degree in Chemical Engineering from Chalmers University of Technology (Sweden, 2006), and doctorate degree in Surface Science and Technology from Department of Materials, ETH Zurich (Switzerland, 2011). During his doctorate research at EHTZ, he has worked on pretty much an inter-disciplinary topic ranging from polymer synthesis, surface modification (including polymer and biomolecule adsorption to surfaces), and surface characterizations by means of different kinds of techniques. This has provided him with an exceptional opportunity to get trained in broad range of disciplines ranging from synthetic organic chemistry to polymer chemistry and materials science; from surface physics and chemistry to biochemistry and microbiology. He has enjoyed working in the inter-disciplinary type of project because of his big desire to explore new research fields and techniques. He also enjoyed discussing with people with different scientific backgrounds.