PPARγ and IL-6-174 G>C gene variants in Croatian patients with ischemic stroke

3^rd International Conference on Genomics & Pharmacogenomics

September 21-23, 2015 San Antonio, USA

Bazina A, Serti�?�? J, Mi�?¡ma�?¡ A, Lovri�?�? T, Poljakovi�?�? Z and Mili�?i�?�? D

University Hospital Centre Zagreb, Croatia

Posters-Accepted Abstracts: J Mol Genet Med

Abstract :

Aim: Etiology of Ischemic Stroke (IS) is multi factorial and includes interaction of genetic and environmental factors. Different genes, their polymorphisms, host susceptibility and inflammation processes play a role in IS development. The aim of this study was to evaluate the effect of PPAR-�?³ and IL-6 gene variants on IS onset. Material & Methods: A total of 301 subjects (144 male, 157 female) participated in the study, 114 patients with IS and 187 healthy controls. Results: Statistically significant predictors of IS were gender (OR 7.13, 95% CI 2.92-17.39, p<0.001), hypertension (OR 7.82. 95% CI 2.53-24.19, p<0.001), lowered HDL cholesterol (OR 8.20, 95% CI 2.41-27.94, p=0.001), C-reactive protein (OR 5.26, 95% CI 1.92-14.41) and IL-6 -174 GC (OR 2.44 95% CI 1.01-5.91, p=0.0048) genotype. Males compared to females had 7 times higher odds for stroke. The presence of hypertension, lowered HDL and elevated C-reactive protein increased the risk of stroke. PPAR�?³ was not statistically significantly associated with stroke. IL6-174 G/C genotype increased the odds for IS for 2.4 times. Conclusion: We can point to the IL-6-174 G>C polymorphisms as candidate gene marker and risk factor for the prediction of ischemic stroke.

Biography :

Email: antonelabazina@gmail.com