Predicting value of cytogenetic monitoring system in late onset of chronic non infectious diseases

3^rd International Conference on Biomarkers & Clinical Research

July 2-4, 2012 Embassy Suites Las Vegas, USA

Anna Tompa, M�ty�s G. Jakab, Anna Bir� and Jeno Major

Scientific Tracks Abstracts: J Mol Biomark Diagn

Abstract :

Multistep process of carcinogenesis has several genetic and epigenetic changes during accumulation of DNA damages. The modification in cell cycle, and induction of chromosomal aberrations represent the arsenals of biomarkers showing early signs of cell transformation. The most effective approach to avoid cancer is to keep away the cancer causing agent (primary prevention).Biomarkers can be utilized as indicators of exposures, effects and individual susceptibility to cancer. Sampling of biomarkers in relation to exposure may have a great impact on the reliability of mechanism of action. The biomarkers like the presence of high chromosomal aberrations can also indicate the need of intervention in high risk groups. Altogether more than 5000 cases were investigated since 1989 by follow-up genotoxicology monitoring investigations, which were performed among occupationally exposed workers to various carcinogens (e.g. in oil-industry with occupational exposure to benzene or polycyclic aromatic hydrocarbons (PAHs), health care personnel exposed to different cytostatics and/or formaldehyde. Workers exposed to benzene and PAH were monitored for over 20 years now. Results also show that the induction of active prevention together with the improvement of chemical safety at the work-sites is very effective in all biomarkers. However, besides exposure, the results were negatively effected by drug medication and smoking habits. In a follow-up genotoxicological study of nurses, preparing and administering various cytostatic infusions, correlation in the changes of genotoxicity (e.g. increase in the frequency of chromosome aberrations), and alterations in clinical parameters, iron deficiency, anemia, thyroid diseases and other chronic diseases were observed.

Biography :

Anna Tompa is a professor of Semmelweis University (Budapest,Hungary) in public health. After specializing in pathology she went to the United States to study the advanced methodology of experimental cancer research inEppley Institute of Research in Cancer ( Omaha, Ne.) She studied tissue culture methodology, the organ and species specificity on highly differentiated liver, pancreatic and lung cells. Her Ph.D thesis was defended in Hungary after two years fellowship in the USA. She was a visiting scientist in DKFZ (Heidelberg) from 1986 to 1989. Following this period, she focused on ways of preventing tumors triggered by exposure to occupational carcinogens.