Preparation and characterization of chitosan encapsulated Fe₃O₄@ MIL-100 metal organic framework as a new drug delivery system

Nazila Gholipour,Mehdi Rahimi-Nasrabadi

Baqiyatallah University of Medical Sciences, Iran

Scientific Tracks Abstracts: Chem Sci J

Abstract :

In recent decades, new drug delivery systems that have vital applications in targeted and specialized therapies are on the rise. These researches have provided a good basis for the use of new carriers, including the porous metal-organic framework (MOF), in targeted drug delivery systems. In this research, the magnetic MIL-100 was prepared using the hydrothermal methods. Also, these nanostructures were coated with folate-chitosan. The obtained magnetic carriers characterized by various techniques such as X-ray diffraction, field emission-scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometer and Fourier transform infrared. The effect of hydrothermal conditions e.g. temperature, solvent and metal to ligand ratio on the morphology and size of prepared nanocomposites have been investigated. The sizes of magnetic nanoparticles have an impact effect on the drug encapsulation efficiency and release performance. The in-vitro release of curcumin from MIL-100@Fe₃O₄/chitosan carriers was investigated. Curcumin was efficiently released from magnetic carriers into environment under acidic pHs.

Biography :

Nazila Gholipour has completed her PhD in Radiopharmacy in 2013 from Tehran University of Medical Sciences. She is a Faculty Member at Baqiyatallah University of Medical Sciences as an Assistant Professor from 2014 until now.

E-mail: nazilagholipour@gmail.com