Production of polymeric menthol nanoparticles by solvent displacement method

International Conference on Pharmaceutical Chemistry

September 05-07, 2016 Frankfurt, Germany

Naveeta Kumari, Roberta Peila, Ada Ferri and Antonello A Barresi

Politecnico di Torino, Italy

Posters & Accepted Abstracts: Med chem

Abstract :

This work was carried out with the aim to produce menthol-loaded PEG nanoparticles for transdermal application (NP�s) using two intensive mixers namely confined impinging jet mixer (CIJM) and multi inlet vortex mixer (MIVM) with similar polymer, solvents and operating conditions. Influence of various process parameters such as polymer and menthol concentration, flow rate, solvent type, quench ratio etc., on mean nanoparticle size, zeta potential, menthol loading and encapsulation efficiency were compared and investigated. The amount of menthol encapsulated inside the nanoparticles was quantified by gas chromatography. In addition, for further investigation about the structure, texture, shape and size the NP nanoparticles were analyzed with TEM technique. A simple equation showing the dependence of mean nanoparticles size on initial polymer concentration, mass ratio, flow rate (or inlet stream velocity) was proposed and by experimental investigation parameters it was confirmed. Nanoparticles of size between 200 nm to 800 nm were produced using the CIJM and MIVM with different configurations. It was observed that the CIJM mixer produced larger mean nanoparticle size as compared to two (MIVM-2) and four (MIVM-4) sided streams vortex mixers and; as concerns the influence of the solvent, larger mean nanoparticles were obtained with acetonitrile as compared to acetone. Encapsulation efficiency and menthol loading increased with increasing menthol and polymer concentration during the nanoparticles synthesis. Few experiments with miglyol oil were also carried out with the aim to optimize NP mean size.

Biography :

Email: naveeta.kumari@polito.it