Prognostic significance of DNMT3A mutations in patients with acute myeloid leukemia

7^th Global Summit on Cancer Therapy

October 05-07, 2015 Dubai, UAE

Lamya Mohamed Mahmoed Ibrahem

Mansoura University, Egypt

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Background: Acute myeloid leukemia (AML) represents a heterogeneous group of malignancies with great variability in clinical course and response to therapy. Several molecular markers have been described that help to classify AML patients into risk groups. Mutations in DNA methyltransferase 3A (DNMT3A) gene were recently demonstrated in AML. Approximately 20% patients with AML carry DNMT3A gene mutations and were associated with a poor clinical outcome but its clinical implications in Egyptian AML patients are largely unknown. Aim: To study the incidence and prognostic impact of DNMT3A mutations in patients with de novo acute myeloid leukemia. Patients and Methods: A total of 120 patients with de novo AML were examined for mutations in DNMT3A by sequencing. Results: In the present study of 120 patients with de novo AML, DNMT3A mutations were identified in 34/120 (28%) of AML patients. 15 patients with M4, 14 patients with M5, 3 patient with M2 and 2 patient with M6. DNMT3A mutations were more frequently associated with older age, higher platelet counts and intermediate- risk. DNMT3A-mutated patients did not differ regarding complete remission (CR) and disease-free survival (DFS), but had shorter overall survival (OS; P= 0.048) than DNMT3A� wild-type patients. Mutations in DNMT3A independently predicted a shorter OS (P= 0.049, OR=3.530, 95% CI= 0.706-5.328) by multivariate analysis. Conclusion: We concluded that DNMT3A mutations are highly frequent in Egyptian patients with AML and are associated with an unfavorable prognosis.

Biography :

Lamya Ibrahem is currently working as an Assistant Professor of Hematology and Clinical Pathology at Clinical Pathology Department of Mansoura University, Egypt. She has completed her MBBCH (Medical Bachelors and Bachelors of Chrurgia) in Medicine and Surgery on November 1997 from Mansoura University and completed her MD in Clinical Pathology (Hematology) on topic “Application of flow cytometry in detection of platelet antibodies” from Mansoura University.

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