V R Santos, V R A S Noronha, E N Abdo, L C Noman-Ferreira, F M V D da Silva, L F Correa and F P C L Persio
Minas Gerais Federal University(UFMG), Faculty of Dentistry, Belo Horizonte, Minas Gerais, Brazil
Posters-Accepted Abstracts: J Cancer Sci Ther
Background:Oral Mucositis refers to oral mucosa erythematous and ulcerative lesions and is caused by radiation dispensed in the treatment of malignant tumors of the head and neck. Propolis shows several biological activities such as antimicrobial, anti-inflammatory, anesthetic and cytostatic properties. These biological activities should prevent a mucositis.Aim: Verify the effectiveness of Brazilian green propolis in a mucoadhesive gel, alcohol free, in preventing oral mucositis in patients that underwent radiotherapy in head and neck region. Methods: This research is characterized as a phase II study with a mean duration of 12 weeks of patients follow-up. The selection of participants groups was randomized, conditioned especially to the availability of the patients during radiotherapy. All patients signed informed consent prior to participation. Results: The 26 selected patients were distributed between two groups, 13 in the benzydamine group and 13 in the propolis group. Patients were assessed on an average of 4.5 times totaling 116 diagnoses of mucositis. The percentage of patients who had mucositis greater or equal to 2 in this study was 30.6% for the benzydamine group and 29.6% for propolis gel. For these patients the propolis gel shows a better performance in maintaining lower rates/grades and recovery of patients from the 17th session of radiotherapy. Conclusion: the mucoadhesive gel propolis showed better results than benzydamine hydrochloride. However, a larger number of patients in phase III study should be approached to confirm these results.
Email: vegneer2003@yahoo.com.br
Cancer Science & Therapy received 5282 citations as per Google Scholar report
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