Prostate leiomyo sarcoma and carcino sarcoma: Report of 2 cases

International Conference on Prostate Cancer

June 22-24, 2015 Florida, USA

Engin Kaya1, Serdar Yalcın1, Nuri Yigit1, Sami Uguz1, Turgay Ebiloglu2, Nuri Karadurmus1, Ismail Hakkı Ozerhan1 and Yusuf Kibar1

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Introduction: Treatment of prostate sarcom as are still challenging due to the poor prognosis. We here in present a case of prostatic carcino sarcoma and concurrent primary prostatic sarcoma and acinaradeno carcinoma. Patients & Methods: Case 1: A 40-year-old man presented with complaints of constipation and prostatism. On digital rectal examination, an arrowing rectal lumen with large mass originated from prostate was found. A serum prostate spesific antigen (PSA) was 2, 2 ng/ml. MRI revealed a largemass, 50x51x43 mm in dimensions, arising in left prostate lobe. Rectal wall could not be distinguished from the prostate tissue. 12 cores of prostate biopsies were performed and all of them were reported as leiomyo sarcoma. Thoracal CT showed multiple nodules, compatible with metastasis in bilateral lung. Three cycles of neo adjuvant chemotherapy was implemented and the metastatic foci were quickly regressed. After the chemotherapy, we performed radical prostatectomy, uretrectomy, low anterior resection, vesicostomy and colostomy. Histopathologic examination showed acinaradeno carcinoma with a Gleasonscore 6 (3+3) and primary leiomyo sarcoma extensively infiltrating neighborings of tissues and rectalwall. Case 2: A 63-year-old man was admitted to our hospital with a history of newly diagnosed prostatic acinaradeno carcinoma which was Gleasonscore 8 (3+5). PSA level was 5, 99 ng/ml. Thoraco abdominal CT indicated two enlarged obturator lypmhnodes in abdomen. Bone scan was normal. Cystoscopy revealed extremely large prostate and possible bladder neck invasion. Second TUR-P was performed and histopathologic examination showed carcino sarcoma of prostate. Radical prostatectomy, obturator lymph node dissection, uretrectomy, partial cystectomy and vesicostomy were performed. Histopathologic examination revealed primary prostatic which was located in both lobes of prostate with extensive carcino sarcoma showed all biopsy samples pathology after surgery, radiotherapy was planned. Conclusion: Leiyomyo sarcoma and carsino sarcoma of the prostate are rare neoplasm which usually presents with metastatic disease. Multi modal treatment options including surgery, pre operative and post operative radiotherapy and chemotherapy can be performed. Despite all treatment options, these neoplasm cause a poor prognosis.