Protective effect of Garcinia indica fruit rind (Kokum) against fructose and high fat diet induced abnormalities associated with the metabolic syndrome in rats

Joint Event on 3^rd International Conference on ENDOCRINOLOGY AND METABOLIC SYNDROME & 12^th International Conference on ABDOMINAL IMAGING AND ENDOSCOPY

June 28-29, 2018 Amsterdam, Netherlands

Alok D Singh, Vandana Panda and S Sudhamani

Principal K M Kundnani College of Pharmacy, India
Dr. D Y Patil Medical College, India

Posters & Accepted Abstracts: J Metabolic Synd

Abstract :

The present study evaluates the protective effects of Garcinia indica fruit rind extract (GIE) in abnormalities associated with the metabolic syndrome (MetS) in rats. Rats administered with high fat diet (HFD) and fructose (20% w/v) in drinking water for 45 days to induce abnormalities associated with the MetS. Rats received GIE (400 and 800 mg/kg, po), the standard drug gemfibrozil (60 mg/kg, po), aerobic exercise (AE), and combination of GIE 800 mg/kg and AE (GIEAE) daily for 45 days. All treatment animals showed a significant reduction in food intake, body weight, body mass index (BMI), and abdominal circumference (AC). A significant decrease in blood glucose and insulin levels decreased insulin resistance, and improved glucose tolerance was observed in the treatment animals when compared with HFD and fructose fed animals. All treatment significantly altered lipid profile and attenuated the levels of uric acid, C-reactive protein, TNF-α, and marker enzyme (AST, LDH and CK-MB) in serum and malondialdehyde in heart and restored the depleted levels of glutathione and antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) and significant elevation was observed in adiponectin levels. The best mitigation was shown by GIEAE treatment indicating that regular exercise along with adequate consumption of antioxidant and polyphenol rich kokum in diet can help control MetS.

Biography :

E-mail: aloksingh463@gmail.com