Protective potential of Euphorbia neriifolia and its isolated flavonoid against N-Nitrosodiethylamine induced hepatic carcinogenesis in Swiss albino mice

9^th Indo Global Summit on Cancer Therapy

November 02-04, 2015 Hyderabad, India

Pracheta

Banasthali University, India

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

The aim of this study was to examine the impacts of N-Nitrosodiethylamine (DENA), a potent environment carcinogen on liver tissue of mice which was attenuated by isolated flavonoid and hydro-ethanolic extract of Euphorbia neriifolia (HEEN) leaves. Carcinogenicity was induced in albino mice by a single oral administration of DENA (50 mg/kg body weight). The HEEN (150 and 400 mg/kg body weight), butylated hydroxyanisole (BHA; 0.5 and 1%) and E. neriifolia flavonoid (ENF; 50 mg/kg body weight) were estimated to examine the possible anti-cancer potential. DENA exposed animals showed alterations in normal hepatic histo-architecture which comprised of necrosis (N), dilated sinusoids and vacuolization of the cells. Mice treated with E. neriifolia lower (ENL) and higher (ENH) dose and ENF before intoxicated with DENA showed that the liver cells were normal with very little necrosis (Day 31). On the other hand, BHA higher (BHAH) and lower (BHAL) dose failed to diminish the abnormalities caused by the DENA. A result of the present study suggests that the ENH and ENF protect the hepatic tissue against DENA-induced hepatic carcinoma. The results could also be expressed in the order of ENH>ENF>ENL>BHAH>BHAL.

Biography :

Email: pracheta.25@gmail.com