Regioselective C-H alkylation via carboxylate-directed hydroarylation in water

9^th World Congress on Green Chemistry and Technology

September 17-19, 2018 | Amsterdam, Netherlands

Guodong Zhang and Lukas J GooBen

Ruhr-Universitat Bochum, Germany

Posters & Accepted Abstracts: J Environ Anal Chem

Abstract :

In the presence of catalytic [Ru(p-cym)Cl2]2 and using Li3PO4 as the base, benzoic acids react with olefins in water to afford the corresponding 2-alkylbenzoic acids in moderate to excellent yields. This Câ??H alkylation process is generally applicable to diversely substituted electron-rich and electron-deficient benzoic acids, along with a,b-unsaturated olefins including unprotected acrylic acid. The widely available carboxylate directing group can be removed tracelessly or utilized for further derivatization. Mechanistic investigations revealed that the transformation proceeds via a ruthenacycle intermediate.

Biography :

Guodong Zhang has completed his Master’s degree from Zhengzhou University in China. Currently, he is pursuing his PhD at Ruhr-Universität Bochum, supervised by Lukas J Gooßen.

E-mail: guodong.zhang@rub.de