Regulation of LncRNA-MIF in c-Myc homeostasis

16^th Global Annual Oncologists Meeting

April 24-25, 2017 Dubai, UAE

Mian Wu

University of Science and Technology of China, China

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

c-Myc is one of the most important proto-oncogenes and is activated in over half of human cancers. However, it remains unclear how the c-Myc protein level is regulated. Here we show that lncRNA-MIF (c-myc inhibitory factor), a c-Mycinduced long non-coding RNA, acts as a competing endogenous RNA (ceRNA) for miR-586 and reduces the inhibitory effect of shared miR-586 on Fbw7, an E3 ligase for c-Myc, leading to increased Fbw7 level and subsequent c-Myc degradation. This creates an autoregulatory feedback loop between c-Myc and Fbw7 that involves both a long and a micro noncoding RNAs. Interestingly, levels of all components of this network including c-Myc, lncRNA-MIF, miR-586 and Fbw7 are found to be higher in tumor cells than in normal cells. The c-Myc-lncRNA-MIF-miR-586-Fbw7 axis represents a novel mechanism by which c-Myc homeostasis is finely regulated. Additionally, lncRNA-MIF is able to inhibit the glycolysis and tumorgenesis via suppressing c-Myc.

Biography :

Mian Wu has completed his graduation from Nanjing Normal University in 1981 (BS) and obtained his PhD degree from Columbia University, USA in 1988. He then continuously conducted his Post-doctoral research at Harvard University during 1988-1991. Thereafter, he moved to Singapore as an Assistant Professor at School of Biological Sciences of National University of Singapore. From 2000, he worked as a full Professor at University of Science and Technology of China in Hefei, Anhui. His research interests focus on molecular mechanisms for p53-regulated tumor development and regulation of non-coding RNA in tumor metabolism. He has published more than 60 research papers in international peer-reviewed journals with more than 2900 citations.

Email: wumian@ustc.edu.cn