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Relation of anthropometric measures and insulin resistance with Anti-Mullerian hormone in premenopausal women
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Journal of Metabolic Syndrome

ISSN: 2167-0943

Open Access

Relation of anthropometric measures and insulin resistance with Anti-Mullerian hormone in premenopausal women


Joint Event on 3rd International Conference on ENDOCRINOLOGY AND METABOLIC SYNDROME & 12th International Conference on ABDOMINAL IMAGING AND ENDOSCOPY

June 28-29, 2018 Amsterdam, Netherlands

Eman H El-Adawy, Maha M Elshafei, Mohamed Sherif Abd Elgawad and Soma sheriff Abd EL Gawad

Mansoura University, Egypt
Specialized Medical Hospital, Egypt

Posters & Accepted Abstracts: J Metabolic Synd

Abstract :

Introduction: It has been suggested that obesity is associated with decreased level of Anti-Müllerian hormone (AMH) which considered as a good marker of ovarian reserve. Aim: The aim of this study was to evaluate the association between obesity and AMH and whether there is relation of the anthropometric measures and insulin resistance with the level of AMH in Egyptian premenopausal women. Subjects & Methods: Eighty premenopausal women with BMI more than 30 (obese group) and 80 age-matched healthy lean women (control group). BMI, waist circumference (WC), blood pressure (BP) were measured. Fasting blood glucose (FBS), fasting insulin (FI), insulin resistance (HOMA-IR), high sensitive C-reactive protein (hs-CRP) and AMH were analyzed. Results: AMH levels in obese group were significantly lower than control group. There were significant negative correlations between each of BMI, WC, FBG, hs-CRP, FI and HOMA-IR with AMH (r=-0.214, -0.226, 0.141, -0.264, -0.241 and -0.258 respectively) (all p values ≤0.05). With forward stepwise linear regression analysis we found that HOMA-IR was significantly and independently related to AMH; (B= -0.172; 95% CI=-0.273: -0.071). Furthermore, HOMA-IR was confirmed to be an independent predictor of AMH after adjustment of age and BMI; (B=-0.173; 95% CI–0.274; -0.072) and also by adjustment of age and WC; (B=-0.135 95% CI-0.268; -0.001). Conclusion: Obesity and insulin resistance are associated with decreased ovarian reserve among Egyptian premenopausal women.

Biography :

E-mail: emaneladawy@yahoo.com

 

Google Scholar citation report
Citations: 48

Journal of Metabolic Syndrome received 48 citations as per Google Scholar report

Journal of Metabolic Syndrome peer review process verified at publons

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