Renal effects by animal toxins

8^th World Nephrology Conference

August 15-16, 2016 Sao Paulo, Brazil

Aline Diogo Marinho

Federal University of Ceara, Brazil

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Animal toxin envenomation is an important health problem in the tropics. Animal toxins are complex compounds produced by animals for predation, digestion and protection, consisting of peptides, enzymes, chemicals and proteins. At the clinical level, acute kidney injury (AKI) with renal failure has been observed in animal toxin poisoning. The kidney, as a highly vascularized and excretory organ, is a prime target for such toxins. In this work, we review various toxins responsible for renal effects in isolated rat kidney system. Studies with venom from Bothrops jararaca; B. jararacussu; B. moojeni; B. pirajai; B. insularis; B. marajoensis; B. eritromelas; B. leucurus; B. pauloensis; Crotalus durissus cascavella; Tityus serrulatus scorpion and sea anemone Bunodosoma caissarum. The system provides perfusion pressure (PP), renal vascular resistance (RVR), urinary flow (FU), glomerular filtration rate (GFR), percentage of tubular sodium transport (%TNA+), of chloride (%TCl-) and potassium (%TK+). For example B. pauloensis showed effects similar to B. leucurus and Bothrops marajoensis. The venom reduced PP, RVR, UF, GFR and %TNA+. B. moojeni and B. jararacussu venom showed some toxic effects similar to the other above mentioned examples. These changes in activity can be explained also by the difference in concentration of certain components that act in synergy. In higher concentrations, some venom components can enhance or inhibit the action of others, promoting extremely contradictory or opposite effects. Nevertheless, animal toxins are an important area for research in physiology, pharmacology and drug discovery.

Biography :

Email: alinediogo_marinho@hotmail.com