Renin angiotensin system: Novel perspectives to physical trainers

International Conference on Sports Medicine and Fitness

March 23-25, 2015 Chicago, USA

Lenice Kappes Becker

Posters-Accepted Abstracts: J Sports Med Doping Stud

Abstract :

Date show an important interaction between the rennin angiotensin system and physical exercise in different tissues, this association is present in health or disease. The Angiotensin-(1-7) and physical exercise has been shown important dealings to ameliorate diseases like hypertension, in different models: Two-kidney one-clip hypertensive rats, spontaneously hypertensive rats, in chronic failure, preeclampsia model or in diabetes. This interaction has been evidenced through an increase in ACE2/Ang(1-7)/Mas axes activity. Date with knockout animals or using antagonist, show that Mas receptor is crucial to exercise effects, in addition ACE2 activity is normalize through physical exercise. Date from our laboratory show that the oral formulation of Ang-(1-7) can protect against muscle damage induced by physical exercise in rats and in mice Knockout to Ang-(1-7) receptor, in addition, in humans the oral formulation of Ang-(1-7) induced lower levels of muscle damage marker and reduce a subjective pain scale after strength exercise.