Ahmed Abugharib
Sohag University, Egypt
Posters & Accepted Abstracts: J Cancer Sci Ther
Objective: The main purpose of this study is to compare the biochemical relapse free survival and the overall survival in both low and intermediate risk prostate cancer patients treated with either intensity modulated radiation therapy (IMRT) alone vs., low dose brachytherapy followed by intensity modulated radiation therapy (COMPO). Material & Methods: 100 low and 215 intermediate risk prostate cancer patients (total of 315), treated in university hospital and cancer institute in the period between 2002 and 2007 using either IMRT alone (165 patient) or low dose brachytherapy (using permanent iodine-125 implantation) followed by IMRT (150 patients). The data of these patients were collected and analyzed to detect any difference in the biochemical relapse free survival and overall survival between the groups. Results: The median follow up of the patients was 7 years. Analysis of the collected data revealed statistically significant improvement in the biochemical relapse free survival in the intermediate risk group treated with COMPO (low dose brachtherapy followed by IMRT) when compared with the intermediate risk group treated with IMRT alone (P=0.004). However there was no statistically significant difference in the biochemical relapse free survival in the low risk group (p=0.08). Also there was no difference in the overall survival in either low or intermediate risk groups. Conclusion: The use of COMPO treatment (low dose brachytherapy followed by intensity modulated radiation therapy) in the intermediate risk prostate cancer patients is associated with significant improvement in the biochemical relapse free survival when compared with the IMRT alone.
Email: oncologymaster83@yahoo.com
Cancer Science & Therapy received 3968 citations as per Google Scholar report
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