Review of genomics of Barrett’s esophagus and esophageal adenocarcinoma

7^th Global Summit on Cancer Therapy

October 05-07, 2015 Dubai, UAE

Sadir J Al Rawi, Khaled Assim Karkout, Amgad El Sherif, Ali Aldameh and Dongfeng Tan

Tawam Hospital, UAE

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

In Barrett�s esophagus, esophageal epithelium is replaced by intestinal type columnar epithelium. Esophago gastroduodenoscopy, endoscopic ultrasonography and biopsy are advanced diagnostic tools for Barrett�s esophagus. Histological corroboration of endoscopically visible columnarisation results in highest diagnostic accuracy. Surveillance endoscopy with an intensive biopsy every 3 months is recommended after dysplasia is identified. Endoscopic ablation is the first line therapy in that case. Ablation can result in squamous re-epithelialization although rests of glandular metaplasia may remain beneath the neo-squamous epithelium Thus ablation remains experimental until further prospective randomized studies. Surgical resection alleviates the symptoms of acidic reflux but does not decrease the risk of progression from Barrett�s esophagus to esophageal adenocarcinoma. Protein pump inhibitors have been linked to a decreased risk of developing esophageal adenocarcinoma, if they are used for more than 2 to 3 years. However, it is unknown whether they can inhibit progression from Barrett�s esophagus to esophageal adenocarcinoma. Linkage between proton pump inhibitors and the genomics of the Barrett�s esophagus and esophageal adenocarcinoma is still unclear yet. Studies have focused on the risks of the long term suppression of gastric acidity in the prevention and treatment of Barrett�s esophagus. However; only few studies are available regarding genomics of this condition. In this review we discuss the genomics of Barrett�s esophagus and esophageal adenocarcinoma. We try here to collect the most recent data on this topic and make it readily available for researchers and reviewers.

Biography :

Sadir Al Rawi currently is the Chief of Surgical oncology division at Tawam Hospital and is the interim Chair of Department of surgery since October 2013. Prior to that, Alrawi was an assistant professor in the Department of Surgery/Division of Surgical Oncology at University of Florida, Jacksonville. He trained in various academic institutes in Surgical Oncology all over including Roswell Park, Cancer institute, Buffalo, Royal Free Hospital, UC of London and Ninewells Hospital, Dundee, United Kingdom. Sadir Al Rawi is American board certified, completed his Head & Neck fellowship and Surgical Oncology fellowship at Roswell Park Cancer institute (NCI) designated in 2006. Dr Alrawi did advanced Laparoscpic oncology training with Professor Alfred Cuschieri in Dundee 1992-1993, advanced colorectal oncology training with E Lloyd Davis in Cornwall, England 1993-1995 and advanced surgical oncology with Professor Marc Winslett, London 1995-1996.

Email: sjalrawi@tawamhospital.ae