Rutin Attenuates Neuroinflammation in Spinal Cord Injury Rats

International Conference on Spine and Spinal Disorders

June 30-July 02, 2016 Valencia, Spain

Wu Jiang

Nanjing Medical University, Affiliated Hangzhou Hospital, China

Scientific Tracks Abstracts: J Spine

Abstract :

Background: Neuroinflammatory responses involve the activation of the interleukin (IL) -1�² and IL-18. Processing and activation of the pro-inflammatory IL require NLRP3 inflammasome activation. Rutin can protect spinal cord against damange, but the potential mechanisms underlying remains unknown. Here, we investigated the molecular mechanisms of rutin-mediated neuroprotection in a rat model of spinal cord injury(SCI). Materials and methods: One hundred and twenty female Spragueâ��Dawley rats were randomly assigned to four groups: sham group, SCI group, SCI + Rutin50 group, and the SCI + Rutin100 group. The influences of rutin on inflammatory marker levels, histological alterations, and locomotion scale were analysed. Results: SCI significantly increased the expression of the NLRP3, ASC, IL-1�², IL-18 and tumor necrosis factor-a (TNF-a). Rutin significantly reduced the levels of reactive oxygen species (ROS), malondialdehyde (MDA), NLRP3, ASC, caspase-1, IL-1�², IL-18, and TNF-a. Furthermore, rutin administration significantly attenuated histological alteration and improved locomotion recovery. Conclusions: Our data provide clear evidence that rutin attenuates tissue damage and improves locomotion recovery, and the mechanism may be related to the alleviation of inflammation and oxidative stress.

Biography :

Wu Jiang Graduated from Anhui Medical University and studied in General Hospital of Beijing Military Command. Work on experimental study of spinal cord injury.

Email: drjiangwu@163.com