Search for effective antimycotic agents against Microsporum gypseum from 61 ethno medicinal plants of Hyderabad-Karnataka region, India

3^rd International Conference and Exhibition on Biowaivers, Biologics & Biosimilars

October 27-29, 2014 Hyderabad International Convention Centre, Hyderabad, India

Shivakumar Singh P and Vidyasagar G M

Posters: J Bioanal Biomed

Abstract :

The 61 ethno medicinal plants of Hyderabad Karnataka region belonging to 33 different families used in skin diseases were screened for their antidermatophytic properties. Screening was carried out at 5 and 2.5 mg/ml concentrations of pet ether, chloroform, ethyalacetate, methanol and aqueous extracts of each plant by agar well diffusion technique against Microsporum gypseum. Out of 61 plants, 05 (Ceasalpinia bonducella, Coccinia indica, Corchorus oleterius, Lawsonia inermis and Tridax procumbens) showed very effective antidermatophytic activity in ethyl acetate, chloroform and in aqueous extracts, effective activity observed in 11 plants (Achyranthes aspera, Allium sativam, Celosia argentea, Citrus medica, Curcuma longa, Emblica officinalis, Gymnosporia montana, Lycopersicon esculentum, Milletia pinnata, Ricinus communis, Zingiber officinale) in different extracts, whereas 38 plants showed moderate activity, 07 plants (Euphorbia tirucalli, Lantana camara, Mentha viridis, Tinospora cordifolia and Tridax procumbens) showed weak activity. The minimum inhibitory concentrations of 05 very effective plants were determined. The potential minimum inhibitory concentrations of 0.15 mg/ml conc. were detected from C. indica. This study provides scientific base for the isolation and purification of antidermatophytic compound(s) from ethno medicinal plants.