Sentinel lymph node mapping in women with early stage of cervical cancer by using carbon nano particles suspension injection in laparoscopic surgery

Joint Event on 4^th Annual Conference on Preventive Oncology & 4^th Annual Conference on Gynecologic Oncology, Reproductive Disorders Maternal-Fetal Medicine & Obstetrics

July 18-19, 2018 | Atlanta, USA

Liping Han, Sai Priyanka Boggavarapu, Yuan Li, Zhong Yun, Yuan Yidan, Tan ChaoYue, Guo Rui Xia, Bian Ai Ping, Li Liu Xia and Ji Mei

Zhengzhou University, China

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Objective: Our objective was to determine the feasibility and detection rates for sentinel lymph node (SLN) mapping in early stage of cervical cancer by using Carbon Nano Particles (CPN) in patients who have undergone laparoscopic surgery.

Methods: A total number of 98 women from between December 2016 to August 2017 with early stage of cervical cancer with International federation of gynaecology & obstetrics (FIGO) stage IA1 â?? IIA2 underwent laparoscopy or robotic-assisted radical hysterectomy surgery with attempted SLN mapping by using carbon nano particles suspension injection (CNP dye) with total of 1ml at 3and 9â??o clock. The removal of clinically enlarged or suspicious pelvic lymph nodes according to institutional protocols was performed. All lymph nodes were examined with conventional haematoxylin and eosin (H&E).

Results: The SLN detection rates using CNP were 89%, 98 women with median age of 49.0 years, and the median body mass index (BMI) was 24.3 kg/m2 were included. A total of 4 (4.10%) patients had FIGO stage IA1, 4 (4.10%) had IA2, 40 (41.0%) had IB1, 11(11.20%) had IB2, 23 (23.4%)had IIA1, and 16(16.2%) had IIA2. Histologically, most patients n=83 (84.70%) had squamous cell carcinoma and n=15(15.3%) had adenocarcinoma. 13 cases of metastasis were identified (13.26%). Most patients underwent laparoscopic radical hysterectomy n=66 (67.34%), 31 (31.6%) patients underwent robotic-assisted radical hysterectomy and one patient (1.0%) patient underwent cold knife conization. The median clinical tumor size was 2.0 cm (range, 0â??4.0), and 90.8% of tumors were â?¥2 cm and the patients with lymph vascular space invasion (LVSI) n=44(44.89%). A total of 2050 PLNs were removed from 98 patients. The average number removed 35PLNs for each patient. The total number of SLNs resection was 196nodes, accounting for 9.56% of total PLNs (196/2050). The average number of SLN detected was 4. which were distributed in the obturator, internal iliac, external iliac, common iliac and para-aortic regions. SLNs were most identified at obturator (38.30%), external iliac (36.70%), internal iliac (12.80%), common iliac (6.60%), parametrical (2%), paraâ??aortic (2.60%) and sacral (1%).

Conclusion: SLN mapping with CNP (carbon nano particles) is feasible and results in high detection rate in patients with <2-cm-diameter cervical cancer. Laparoscopic surgery is the best procedure for SLN detection in patients with early-stage cervical cancer. Ongoing studies seek to validate these findings and determine the impact of sentinel node biopsy on quality of life in these women. Multicentre large samples studies are needed to show the feasibility of CNP in early stage of cervical cancer.

Biography :

Liping Han has received her Doctoral degree from Zhengzhou University School of Medicine, Zhengzhou, Henan Province, China. She is presently working as a Professor in the Department of Obstetrics & Gynecology, the First Affiliated Hospital of Zhengzhou University, Henan, China. She has published more than 12 papers and is a member of Chinese Medical Association.

E-mail: hanliping0825@163.com