Short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique

9^th International Conference on Dialysis and Renal Care

August 18-19, 2016 London, UK

Xiu-Wu Han

Beijing Chaoyang Hospital, China

Keynote: J Nephrol Ther

Abstract :

Objective: The objective of the study is to evaluate the clinical safety and efficacy of the retrograde perfusion technique in kidney transplantation. Methods: Between January 2001 and June 2011, 24 cases of kidney transplantation with kidneys perfused using the retrograde perfusion technique due to renal artery variations or injury were selected as the observation group (retrograde perfussion group, RP group). 22 cases of kidney transplantation via conventional perfusion were chosen as the control group (antegrade perfusion group, AP group). There were no statistically significant differences in donor data between the two groups. Cold ischemia time, warm ischemia time, renal perfusion time, amount of perfusion fluid, acute renal tubular necrosis, wound infection, urinary fistula, graft kidney function, and the 1-year, 3-year, and 5-year survival rates for the grafted kidney in both groups were observed and recorded. Results: The kidney perfusion time was shorter in the RP group than that in the AP group (3.14�±1.00 vs. 5.02�±1.15 min, P �¼ 0.030). There were 10 cases of acute renal tubule necrosis in the RP group and 5 in the AP group. The length of hospital stay was 40�±14 d in the RP group and 25�±12 d in the AP group. The follow-up time was 3.5-8.5 years (mean 6.25 years). The 1-, 3-, and 5-year survival rates for the grafted kidney were 95.8%, 75.5%, and 65.5% in the RP group and 97.1%, 82.5%, and 68.4% in the AP group, respectively (P>0.05). Conclusions: This study indicates that retrograde perfusion is safe and practicable for cadaveric kidney harvesting and can be regarded as a better alternative or remedial measure for a poorly perfused kidney due to vascular deformity or injury.

Biography :

Xiu-Wu Han has completed his PhD from Capital Medical University, Beijing, China. He is the Director of Department of Urology, Beijing Chaoyang Hospital Affiliated to Capital Medical University (western campus) Beijing 100020, China. He has more than 20 years of experience in kidney transplantation and published more than 40 papers in Chinese and English.

Email: xiuwuhan@163.com