William MacNee
University of Edinburgh, UK
Posters & Accepted Abstracts: J Pulm Respir Med
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airfl ow limitation that is usually progressive and is associated with an abnormal infl ammatory response in the lungs to noxious particles or gases. Th e natural course of COPD is complicated by the development of systemic consequences and comorbidities that have important prognostic implications that infl uence morbidity and mortality. Cardiovascular comorbidities are one of the most frequent comorbid conditions aff ecting patients with COPD and COPD is thought to be a risk factor for the development of atherosclerosis and consequent cardiovascular complications. Th e expiratory volume in the fi rst second of a forced expiratory maneuver (FEV1) is also known to be an independent predictor of cardiovascular complications in COPD. Even a moderate reduction on the FEV1 increases the risk of morbidity and death related to cardiovascular events by two to three times. COPD shares common risk factors with several cardiovascular diseases (i.e., smoking habit) however, several mechanisms have been implicated for the increased prevalence of cardiovascular comorbidity in COPD including systemic infl ammation and ageing mechanisms. Cardiovascular comorbidities in patients with COPD are under-recognized and undertreated and should be actively sought and treated according to usual guidelines. Th is presentation review will discuss the increased incidence of cardiovascular comorbidities and the prognostic implications in patients with COPD. Th e pathogenic mechanisms of cardiovascular comorbidities in patients with COPD will be also reviewed and the management of cardiovascular comorbidities in patients with COPD will be discussed.
Email: W.MacNee@ed.ac.uk
Pulmonary & Respiratory Medicine received 1690 citations as per Google Scholar report
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