GET THE APP

Silicon Carbide Biotechnology for Robust Implantable Neural Interfaces
..

Biosensors & Bioelectronics

ISSN: 2155-6210

Open Access

Silicon Carbide Biotechnology for Robust Implantable Neural Interfaces


9th Euro Biosensors & Bioelectronics Congress

November 29-30, 2018 | Dublin, Ireland

Stephen E Saddow

University of South Florida, Tampa, USA

Keynote: J Biosens Bioelectron

Abstract :

Intracortical neural interfaces (INI) have made impressive progress in recent years but still display questionable long-term reliability. Here, we report on the development and characterization of highly resilient monolithic silicon carbide (SiC) neural devices. SiC is a physically robust, biocompatible, and chemically inert semiconductor. The device support was micromachined from p-type SiC with conductors created from n-type SiC, simultaneously providing electrical isolation through the resulting p??n junction. Electrodes possessed geometric surface area (GSA) varying from 496 to 500 K μm2. Electrical characterization showed high-performance p??n diode behavior, with typical turn-on voltages of ~2.3 V and reverse bias leakage below 1 nArms. Current leakage between adjacent electrodes was ~7.5 nArms over a voltage range of ??50 V to 50 V. The devices interacted electrochemically with a purely capacitive relationship at frequencies less than 10 kHz. Electrode impedance ranged from 675 ± 130 kΩ (GSA = 496 μm2) to 46.5 ± 4.80 kΩ (GSA = 500 K μm2). Since the all -SiC devices rely on the integration of only robust and highly compatible SiC material, they offer a promising solution to probe delamination and biological rejection associated with the use of multiple materials used in many current INI devices. Recent Publications 1. Evans K. Bernardin, Christopher L. Frewin, Richard Everly, Jawad Ul Hassan and Stephen E. Saddow, ??Demonstration of a Robust All-Silicon-Carbide Intracortical Neural Interface,? Micromachines in press (2019). 2. S. E. Saddow, Editor Silicon Carbide Biotechnology: A Biocompatible Semiconductor for Advanced Biomedical Devices and Applications, © 2011 Elsevier LTD, UK ISBN 0-12385-906-9. 3. de Almeida França, K.L., Almeida, A.C.G., Saddow, S.E., Santos, L.E.C., Scorza, C.A., Scorza, F.A. and Rodrigues, A.M., ??GABA a excitation and synaptogenesis after Status Epilepticus??A computational study,? Scientific reports, Nature.com, 8(1), p.4193 (2018). 4. P. Lagonegro, F. Rossi, C. Galli, A. Smerieria, R. Alinovi, S. Pinelli, T. Rimoldi, G. Attolini, G. Macaluso, C. Macaluso, S.E. Saddow, G. Salviati, ??A cytotoxicity study of silicon oxycarbide nanowires as cell scaffold for biomedical applications,? Materials Science and Engineering: C, Vol. 73, pp. 465-471, 2017. 5. S. E. Saddow, Editor Silicon Carbide Biotechnology: A Biocompatible Semiconductor for Advanced Biomedical Devices and Applications, second edition © 2016, Elsevier LTD, UK ISBN 978-0-12-802993-0. 6. Christopher L. Frewin, Evans E. Bernardin, Felix Deku, Richard Everly, Jawad Hassan, Joseph J. Pancrazio and Stephen E. Saddow, ??(Invited) Silicon Carbide as a Robust Neural Interface,? doi: 10.1149/07512.0039ecst, ECS Trans. volume 75, issue 12, 39-45 2016. 7. Bernardin, E., Frewin, C.L., Dey, A., Everly, R., Ul Hassan, J., Janzén, E., Pancrazio, J. and Saddow, S.E. ??Development of an all-SiC neuronal interface device??, MRS Advances, pp. 1?? 6. doi: 10.1557/adv.2016.360 (2016). 8. SE Saddow, CL Frewin, M Nezafati, A Oliveros, S Afroz, J Register, M. Reyes, and S. Thomas, ??3C- SiC on Si: A bio-and hemo-compatible material for advanced nano-bio devices,? 9th IEEE Nanotechnology Materials and Devices Conference

Biography :

Stephen E. Saddow has completed his PhD from The University of Maryland in College Park in 1993. He is Professor of Electrical Engineering and a member of the Biomedical Engineering faculty at the Univesity of South Florida, Tampa, FL. Dr. Saddow’s research interests are to develop wide-bandgap semiconductor materials for biomedical and MEMS/NEMS applications. His prior expertise was in the growth of SiC epitaxial films on Si substrates. Presently he is pioneered the use of SiC for biomedical applications, having demonstrated that 3C-SiC is both bio- and hemo-compatible. His group has demonstrated several advanced biomedical devices, such as microelectrode arrays (MEAs), neural probes, in-vivo and non-invasive glucose sensors, and impedance-based biosensors.

E-mail: saddow@ieee.org

 

Google Scholar citation report
Citations: 6207

Biosensors & Bioelectronics received 6207 citations as per Google Scholar report

Biosensors & Bioelectronics peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward