Simulation of magnetic drug targeting through tracheobronchial airways in the presence of an external nonuniform magnetic field using Lagrangian magnetic particle tracking

International Conference on Medical Physics

August 03-05, 2015 Birmingham, UK

M Gorji-Bandpy

Posters-Accepted Abstracts: J Nucl Med Radiat Ther

Abstract :

Drug delivery technologies are an important area within biomedicine. Targeted drug delivery aims to reduce the undesired side effects of drug usage by directing the active agents near a desired site within the body. Recently, inert superparamagnetic iron oxide nanoparticles added to the nebuliser solution were used to guide aerosol to the affected region of the lung by means of a strong external magnetic field. A range of therapeutic agents, including genes, could be packaged for delivery by this technique. Herein, a numerical investigation of magnetic drug targeting (MDT) using aerosol drugs named polystyrene microparticle (PMS40) in human airways is presented considering one-way coupling on the transport and capture of the magnetic particle using a realistic 3D geometry based on CT scan images. An external non-uniform magnetic field is applied to deliver the aerosol magnetic drug career to specific region. Parametric investigation is conducted and the influence of particle diameter, magnetic source position, and magnetic number (Mn) on the deposition efficiency and particle behavior is reported. According to the results, the magnetic field increased deposition efficiency of particles in target region and the efficiency of deposition. The results also indicate that, the MDT technique has a direct relation with particle diameter increase for magnetic number of 1 Tesla (T) and lower ( ). Also there is an inverse relation between the particle diameter and deposition efficiency when Mn is more than 1 (T). Finally we could determine appropriate properties of the magnetic drug career size and the magnetic source characteristics.