Single loading dose versus standard 24-hour magnesium sulfate in women with severe preeclampsia and eclampsia: A systematic review and meta-analysis

2^nd World Congress on Fetal and Maternal Medicine

July 24-25, 2019 Kyoto, Japan

Dirdrah Aina Crisostomo Salvador and Floriza C Salvador

De La Salle University Medical Center, Philippines

Scientific Tracks Abstracts: J Nurs Care

Abstract :

Objectives: The primary goal of this study is to determine if a single loading dose of Magnesium Sulfate (MgSO4) is comparable to standard 24-hour therapy in preventing seizures with severe preeclampsia and eclampsia.

Study Design: Meta-analysis and systematic review of six randomized controlled trials.

Patients/Subject Selection: Patients diagnosed with severe preeclampsia and eclampsia.

Intervention: Giving of single loading dose only (study group) versus 24-hour MgSO4 therapy (control) in patients with severe preeclampsia and eclampsia.

Outcome Measures: (1) Anti-convulsant effects, (2) Maternal: Loss of deep tendon reflex and oliguria, incidences of caesarean section, hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome, postpartum hemorrhage and intensive care unit admissions, and (3) Neonatal complications: Incidences of Neonatal Intensive Care Unit (NICU) admission, APGAR score at 5 minutes and death.

Results: Occurrence of seizures was similar in both groups. The risk difference of -0.00 (95% Confidence Interval (CI): -0.04 to 0.03; p=0.84) showed no significant difference and the combined studies were found to be homogenous with an I2 of 0.0.

Conclusion: A single loading dose of MgSO4 is comparable in preventing seizures of preeclamptic and eclamptic patients with similar maternal and neonatal complications except for a lesser occurrence of decreased patellar reflex in the study group (pâ?¤000001).

Biography :

Dirdrah Aina Crisostomo Salvador has completed her Residency training in Obstetrics and Gynecology in the Philippines.

E-mail: dirdrahsalvador@yahoo.com