Smart and living implant equipped with active therapeutics and stem cells for regenerative nanomedicine

3^rd Euro-Global Experts Meeting on Medical Case Reports

June 30-July 02, 2016 Valencia, Spain

Nadia Benkirane Jessel

University de Strasbourg, France

Posters & Accepted Abstracts: J Clin Case Rep

Abstract :

Recently, we have reported an active nanostructured collagen implant reinforced with human stem cells for bone regeneration. In our group, we have reported a "Smart Hybrid Materials Equipped with Nanoreservoirs of Therapeutics and stem cells". This unique nanotechnology strategy is used to entrap, protect and stabilize therapeutic agents into polymer coatings acting as nanoreservoirs enrobing nanofibers of implantable membranes. Upon contact with cells, therapeutic agents become available through enzymatic degradation of the nanoreservoirs. As cells grow, divide and infiltrate deeper into the porous membrane, they trigger slow and progressive release of therapeutic agents that, in turn, stimulate further cell proliferation. This constitutes the first instance of a smart living nanostructured hybrid membrane for regenerative medicine. The cell contact dependent bioerodable nanoreservoirs described here will permit sustained release of drugs, genes, growth factors, etc., opening a general route to the design of sophisticated celltherapy implants capable of robust and durable regeneration of a broad variety of tissues.

Biography :

Email: nadia.jessel@inserm.fr