Ankit Jain and Sanjay K Jain
ADINA Institute of Pharmaceutical Sciences, India
Dr. Harisingh Gour Central University, India
Posters & Accepted Abstracts: J Cancer Sci Ther
The present study was aimed to bring forth a multipronged approach for delivery of synergistically active combination of paclitaxeltopotecan (Pac-Top; 20:1, w/w) using surface modified and integrally designed liposomes. Various liposomes (size ~200 nm) viz. Liposomes (Lip), PEGylated liposomes (PL) and FR-targeted PEGylated liposomes (FPL) were developed using thin film casting technique. In vitro drug release study reflected sustained release kinetics at physiological conditions (37�±0.5�°C, pH 7.4) whereas abrupt dispersal (i.e. more than 90%) of liposomal content within 5 min at simulated tumor conditions (41�±1�°C, pH 4). These liposomes were studied for haemolytic toxicity studies, ex vivo pharmacodynamics (OVCAR-3 cell lines), florescence microscopy, and pharmacokinetics in ovarian tumor-bearing mice. Ex-vivo and in-vivo studies in tumor bearing mice documented a potentiated anticancer activity of FPL attributed to multifaceted features viz. thermosenstivity, long circulatory nature and targetability. Such multi-modal tactic of nanomedicine can be a promising tool for safe and efficacious drug delivery to tumor site.
Cancer Science & Therapy received 3968 citations as per Google Scholar report
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