Solubility enhancement techniques

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

Prashant Patil and Sameer Patel

Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor aqueous solubility. For orally administered drugs solubility is one of the rate limiting parameter to achieve their desired concentration in systemic circulation for pharmacological response. Problem of solubility is a major challenge for formulation scientist, which can be solved by different technological approaches during the pharmaceutical product development. Solid dispersion, Micronization, Salt formation, are some of the vital approaches routinely employed to enhance the solubility of poorly soluble drugs but each approach has some limitation and advantages. Novel techniques like Nano-suspension, Supercritical processing, Cryogenic technology may allow greater opportunities in the delivery of poorly soluble drugs. The solubility behavior of drugs remains one of the most challenging aspects in formulation development. The present review is devoted to various traditional and novel techniques for enhancing drug solubility to reduce the percentage of poorly soluble drug candidates eliminated from the development.

Biography :

Prashant Pandurang Patil has completed their bachelor degree in pharmacy from Shivaji University Kolhapur. Currently Mr.Prashant persuing master degree in Pharmaceutics from Tatyasaheb Kore college of Pharmacy Warananagar. He attended several conferences and have sound knowledge of writing scientific literature.