Varsharani B. Khot, Durgacharan A. Bhagwat and John I. D?Souza
Posters: Pharmaceut Reg Affairs
The distribution in particle size is a factor for the processing behaviour of a powder during pharmaceutical manufacturing. There is, however, still a need for reports providing evidence for a correlation between the particle size distribution and the manufacturability of powders. Large granule porosity in wet processed granules has been related to a large fragmentation during compaction, resulting in mechanical stronger tablets. A decreased primary particle size increases the tablet strength. However, this assumption is provided that the particles stay intact during compaction. The interaction between the particles can be complex and depend on physical properties such as particle size, shape, deformation behavior etc. Powder flow properties deteriorate nearly exponentially with decreasing particle size. For a powder exhibiting marginal flow properties during powder handling, granule size enlargement is an effective means to improve flow properties and manufacturability. To obtain constant powder flow of a given formulation, granule/particle size should be carefully controlled. Hence aim of present work was to study particle size distribution and flow properties of granules prepared by different granulation techniques which affect final tablet performance. In this study granules were prepared by different granulation techniques and characterized for its physical properties. Results showed that, primary particle size had a strong effect on granule growth rate, granule size distribution, granule porosity and also on hardness of tablet.
Miss. Varsharani B. Khot is post graduate student of Dept. of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar affiliated with Shivaji University Kolhapur.
Pharmaceutical Regulatory Affairs: Open Access received 533 citations as per Google Scholar report
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