Study of the antiulcer activity of the essential oil of the Cupressaceae tree Juniperus phoenicea L. (1753) in rats

4^th International Conference and Exhibition on Biologics & Biosimilars

October 26-28, 2015 Baltimore, USA

Abdel Halim Harrath1, Manel Jemai Ben Ali2, Amor Hedfi2 and Mossadok Ben-Attia2

1King Saud University, Saudi Arabia 2University of Carthage, Tunisia

Posters-Accepted Abstracts: J Bioanal Biomed

Abstract :

Gastric ulcers are part of a chronic relapsing disease that is well known to be a polyaetiologic chronic disease. Although many classic drugs are available to treat gastric ulcer, herbal medicines have triumphed as a diverse popular therapy and are emerging as an alternative to the available synthetic drugs. The aim of this study was to evaluate the ulcero-protective of essential oil extracted from the leaves of Juniperus phoenicea (EOJp) against HCl/ethanol-induced ulcers in rats. The in vivo pre-treatment with EOJp at oral doses of 50, 75 and 100 mg/kg body weight has potent anti-ulcer activity, which justifies the ethnomedical claims about its significant gastro-protective effect. In fact, the pre-treatment with EOJp significantly decreased the malondialdehyde (MDA) content and increased the activities of Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPx). This effect may be related to an increase in the gastric mucosal defence mechanisms and the results of our study revealed histo-pathological maintaining of the integrity of the mucosa. As a result, the protective effect of the essential oil and its low toxicity requires further study to elucidate the mechanism of action and isolate the active principles.

Biography :

Email: harrath@ksu.edu.sa