Magda Abd El-Ghany Megahed, Thoria M Dawood, Mohammed M Shamsia and Osama G B Abd El-Halim
Alexandria University, Egypt
Posters & Accepted Abstracts: Chem Sci J
Hepatitis C is a disease of significant global impact. The virus infects liver cells and can cause severe inflammation of the liver with long-term complications. Hepatocellular Carcinoma (HCC) is the most frequent primary malignancy of the liver. The pathogenesis of HCC is highly associated to chronic viral hepatitis. Smoking causes a variety of adverse effects on liver. Osteopontin (OPN) is a multifunctional glycoprotein identiï¬ed as one of the leading genes associated with the metastasis of HCC. The study aimed at investigating the effect of heavy smoking on levels of osteopontin and its role in carcinogenesis in patients of hepatitis C. This study was conducted on 75 volunteers .The subjects were divided into four groups, the first group comprised of 15 normal healthy controls. The second was comprised of 10 HCV-negative heavy smokers, the third was comprised of 25 HCV positive cirrhotic nonsmokers (Child-Pugh Class A) and the fourth was comprised of 25 HCV positive cirrhotic smokers (Child-Pugh Class A). The current study revealed a statistically significant elevation of serum levels of osteopontin in hepatitis C-positive patients in comparison to hepatitis C-negative subjects (P<0.001). HCV-positive cirrhotic smokers were found to have significantly elevated levels of serum osteopontin in comparison to HCV-positive cirrhotic nonsmokers (P<0.004). The mean serum osteopontin level in hepatitis C-negative smokers is statistically significantly elevated in comparison to healthy control (p<0.005). It can be concluded that smoking increases levels of osteopontin in sera of hepatitis C-positive smokers in comparison to its levels in hepatitis C-positive nonsmokers. magdamegahed@hotmail.com
Chemical Sciences Journal received 912 citations as per Google Scholar report
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