Surface modification of cardiovascular biomaterials with functional molecules for better biocompatibility

18^th International Conference and Exhibition on Materials Science and Engineering

May 28-30, 2018 Osaka, Japan

Jingan Li

Zhengzhou University, China

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

Cardiovascular disease is generally accepted as the leading cause of morbidity and mortality worldwide and lots of people suffer from atherosclerosis and thrombosis every year. To treat these disorders and prolong the patients� life, the cardiovascular stents have been developed and applied clinically. Nevertheless, thrombosis and hyperplasia at the site of implanting cardiovascular stents are recognized as a long-term problem in the practice of interventional cardiology. Although the drug-eluting stents make excellent contribution to treat early thrombosis and inflammation the loading drugs also delay vascular healing and re-endothelialization, leading to high risk of late thrombosis and hyperplasia. Recent researches show that stent surface modification with functional molecules can significantly improve surface re-endothelialization and reduce the late thrombosis/hyperplasia and this process is closely related to the crucial parameters of the conjugated molecules, including the molecular classification, weight, distributed density and conformation. Therefore, the surface construction of functional molecules is of great importance for improving the biocompatibility of the cardiovascular stents. Here we have introduced several novel strategies on surface modification of cardiovascular biomaterials in our research group and discuss the prospects for extending use of the surface construction of functional molecules in designing the next generation of vascular stents. 4828713@qq.com