Synthesis and antimicrobial screening of 1, 2, 4 H-triazole derivatives

3^rd International Conference and Exhibition on Biowaivers, Biologics & Biosimilars

October 27-29, 2014 Hyderabad International Convention Centre, Hyderabad, India

Neha Yadav, Rita Mourya and Rajiv Dahiya

Posters: J Bioanal Biomed

Abstract :

Azoles are important five membered heterocyclic rings containing at least one nitrogen atom like Isoxazole, Thiazole, Pyrazole and Triazole. We concentrate on 1,2,4-Trizoles, which possess three nitrogen in five membered heterocyclic ring and shows various medicinal properties such as possible hypoglycemic activity, anti-microbial, anti-inflammatory, anticonvulsant anti-tubercular, anti-depressant, and anti-proliferative properties. 1, 2, 4-Triazole derivatives have received much attention due to their versatile biological properties. Hence efforts have been made to synthesis 5-(4 Hydroxyphenyl) 4H-1, 2, 4-triazole-3-thiol and its derivatives and evaluated them for their antimicrobial potential. Compounds 1a, 1c and 1d were found potent against S. aureus and E. coli and compound 1 and 1c displayed better activity against pathogenic fungus A. niger.